AURKC

Across TCGA patient cohorts, AURKC mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AURKC-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Caspase-7-cleavedD198. Each is linked with AURKC in more than 2 cancer types. Because this analysis shows association rather than direction, both AURKC-to-partner and partner-to-AURKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AURKC-low versus AURKC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKC→partner) and Y-score (partner→AURKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.180	+3.013	.038	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.206	-2.000	.003	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.901	+2.479	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.319	-2.321	.002	.006	3	1
UCEC	A-Raf_pS299 →	-0.186	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.232	+2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by AURKC expression — UCEC

Explore this box plot interactively →