AURKC

Across TCGA cell cohorts, AURKC RNA expression is significantly associated with the go_rna of many other GO terms, with 1,780 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AURKC-associated GO terms across cancer lineages are Regulation of protein localization to mitochondrion, Regulation of intracellular protein transport, and Protein targeting to ER. Each is linked with AURKC in more than 6 cancer types. Because this analysis shows association rather than direction, both AURKC-to-partner and partner-to-AURKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to mitochondrion grouped by AURKC-low versus AURKC-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKC→partner) and Y-score (partner→AURKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of protein localization to mitochondrion →	+0.075	+0.569	.001	.008	3	7
BLOOD_Leukemia	Regulation of intracellular protein transport →	+0.035	+0.624	<.001	.001	3	7
SOFT_TISSUE	Protein targeting to ER →	+0.094	+0.431	<.001	<.001	2	7
BLOOD_Lymphoma	Regulation of proteasomal protein catabolic process →	+0.042	+0.499	.002	<.001	3	6
SOFT_TISSUE	Viral process →	+0.056	+0.330	.002	.001	2	7
SOFT_TISSUE	Regulation of intracellular transport →	+0.048	+0.337	<.001	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,780 associations by consensus.

Regulation of protein localization to mitochondrion by AURKC expression — LARGE_INTESTINE

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