AURKC

Across TCGA cell cohorts, AURKC mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AURKC-associated genes across cancer lineages are HNRNPCL4, FAM205A, and GSG1L2. Each is linked with AURKC in more than 1 cancer types. Because this analysis shows association rather than direction, both AURKC-to-partner and partner-to-AURKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPCL4 grouped by AURKC-low versus AURKC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKC→partner) and Y-score (partner→AURKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HNRNPCL4 →	+0.042	+3.115	.004	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+4.029	.002	.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBR1 →	+0.042	+3.333	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

HNRNPCL4 by AURKC expression — LARGE_INTESTINE

Explore this box plot interactively →