ATXN7L3

Across TCGA cell cohorts, ATXN7L3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,877 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATXN7L3-associated GO terms across cancer lineages are Heterochromatin formation, Epigenetic regulation of gene expression, and Negative regulation of gene expression, epigenetic. Each is linked with ATXN7L3 in more than 17 cancer types. Because this analysis shows association rather than direction, both ATXN7L3-to-partner and partner-to-ATXN7L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by ATXN7L3-low versus ATXN7L3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L3→partner) and Y-score (partner→ATXN7L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.073	+0.768	<.001	.001	3	18
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.067	+0.824	.001	.001	3	18
STOMACH	Negative regulation of gene expression, epigenetic →	+0.088	+0.756	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Heterochromatin organization →	+0.066	+0.768	<.001	.001	3	18
OVARY	Transcription initiation-coupled chromatin remodeling →	+0.097	+0.652	<.001	<.001	3	17
URINARY_TRACT	Regulation of G1/S transition of mitotic cell cycle →	+0.063	+0.541	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,877 associations by consensus.

Heterochromatin formation by ATXN7L3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →