ATP8B4

Across TCGA patient cohorts, ATP8B4 mutation is significantly associated with the RNA expression of many other genes, with 6,706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B4-associated genes across cancer lineages are CENPU, SKA1, and MRPL16. Each is linked with ATP8B4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP8B4-to-partner and partner-to-ATP8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by ATP8B4-low versus ATP8B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B4→partner) and Y-score (partner→ATP8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.565	+1.394	<.001	<.001	3	5
UCEC	SKA1 →	+0.605	+2.010	<.001	<.001	3	5
UCEC	MRPL16 →	+0.241	+2.135	.002	<.001	3	5
UCEC	PBK →	+0.729	+1.673	<.001	<.001	3	5
SKCM	MTX2 →	+0.328	+1.754	.001	<.001	3	5
SKCM	SCLT1 →	+0.278	+1.331	.006	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,706 associations by consensus.

CENPU by ATP8B4 expression — UCEC

Explore this box plot interactively →