ATP8B4

Across TCGA pan-cancer cohorts, ATP8B4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ATP8B4 data layer compared with 11 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ATP8B4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ATP8B4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and LUAD are the cancer types where ATP8B4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.401	0.263	<.001	111	view →
HNSC	DFS	Median	All	0.754	0.635	<.001	106	view →
LUAD	OS	Median	All	0.746	0.626	<.001	62	view →
KIRC	DFS	Tertile	All	0.911	0.717	<.001	43	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	28	view →
LGG	DFS	Quartile	All	0.350	0.568	<.001	28	view →
SARC	OS	Quartile	All	0.841	0.595	<.001	27	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	25	view →
CHOL	DFS	Quartile	II,III,IV	0.754	0.151	.006	22	view →
OV	OS	Quartile	III,IV	0.606	0.731	.010	16	view →
LUSC	OS	Quartile	II,III,IV	0.376	0.776	.007	12	view →
READ	DFS	Median	III,IV	0.540	0.202	.014	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ATP8B4–SKCM (OS)

Open the SKCM breakdown →