ATP8B4

Across TCGA pan-cancer cohorts, ATP8B4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ATP8B4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ATP8B4 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP8B4 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and UCEC are the cancer types where ATP8B4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP8B4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.737	<.001	9	view →
COAD	Female	All	−0.475	<.001	9	view →
UCEC	All	All	−1.921	<.001	8	view →
THCA	All	II,III,IV	−0.359	<.001	8	view →
BRCA	All	III,IV	−0.916	<.001	6	view →
KIRC	Male	All	+0.366	<.001	5	view →
KICH	Male	All	+1.425	.001	4	view →
LUSC	Male	II,III,IV	−0.562	<.001	4	view →
HNSC	Female	All	+0.256	.006	3	view →
CHOL	All	II,III,IV	−0.754	.001	2	view →
PRAD	All	All	−0.585	.003	2	view →
LUAD	All	All	+0.321	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ATP8B4–BLCA

Open the BLCA breakdown →