ATP8B4

Across TCGA patient cohorts, ATP8B4 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B4-associated genes across cancer lineages are ASNS, GAPDH, and MEK1. Each is linked with ATP8B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP8B4-to-partner and partner-to-ATP8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ATP8B4-low versus ATP8B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B4→partner) and Y-score (partner→ATP8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.329	+1.459	<.001	.011	3	4
BLCA	GAPDH →	+0.650	+3.169	.004	.019	3	3
UCEC	MEK1 →	+0.341	+2.058	<.001	<.001	3	3
STAD	Cyclin-B1 →	+0.594	+2.321	.004	.034	3	3
UCEC	eIF4E →	+0.181	+1.959	.001	<.001	3	3
UCEC	4E-BP1 →	+0.311	+2.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ASNS by ATP8B4 expression — UCEC

Explore this box plot interactively →