ATP8B4

Across TCGA cell cohorts, ATP8B4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,831 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATP8B4-associated GO terms across cancer lineages are Actin filament fragmentation, Regulation of syncytium formation by plasma membrane fusion, and Negative regulation of ERBB signaling pathway. Each is linked with ATP8B4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ATP8B4-to-partner and partner-to-ATP8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament fragmentation grouped by ATP8B4-low versus ATP8B4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B4→partner) and Y-score (partner→ATP8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Actin filament fragmentation →	+0.087	+1.043	<.001	.004	3	6
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.113	+0.260	.001	.002	2	7
BLOOD_Lymphoma	Negative regulation of ERBB signaling pathway →	+0.061	+1.382	<.001	.007	3	5
PANCREAS	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.091	+0.160	<.001	<.001	3	5
BLOOD_Lymphoma	Regulation of plasma membrane organization →	+0.114	+1.418	<.001	<.001	3	5
BLOOD_Leukemia	Exosomal secretion →	+0.085	+1.795	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,831 associations by consensus.

Actin filament fragmentation by ATP8B4 expression — SOFT_TISSUE

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