ATP8B4

Across TCGA cell cohorts, ATP8B4 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ATP8B4-associated genes across cancer lineages are BTNL2, TEX43, and FAM124A. Each is linked with ATP8B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP8B4-to-partner and partner-to-ATP8B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTNL2 grouped by ATP8B4-low versus ATP8B4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B4→partner) and Y-score (partner→ATP8B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BTNL2 →	+0.031	+4.169	.001	.008	3	2
LUNG_SCLC	TEX43 →	+0.180	+3.523	<.001	.008	3	2
LARGE_INTESTINE	FAM124A →	+0.623	+2.617	.001	.002	3	2
SOFT_TISSUE	FEZF2 →	+0.178	+4.222	<.001	.007	3	1
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
KIDNEY	C1orf158 →	+0.138	+4.121	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

BTNL2 by ATP8B4 expression — CNS

Explore this box plot interactively →