ATP8A2

Across TCGA cell cohorts, ATP8A2 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP8A2-associated genes across cancer lineages are OR11H1, C8B, and MAGEB5. Each is linked with ATP8A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP8A2-to-partner and partner-to-ATP8A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by ATP8A2-low versus ATP8A2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8A2→partner) and Y-score (partner→ATP8A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR11H1 →	+0.044	+4.421	<.001	.004	3	2
SKIN	C8B →	+0.035	+2.882	.001	.005	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	MAPK3 →	-0.811	-3.657	<.001	<.001	3	1
LARGE_INTESTINE	C3orf52 →	-0.672	-2.541	.005	.005	3	1
LARGE_INTESTINE	EIF1B →	+0.452	+2.714	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

OR11H1 by ATP8A2 expression — BREAST

Explore this box plot interactively →