ATP8A2

Across TCGA pan-cancer cohorts, ATP8A2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ATP8A2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATP8A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP8A2 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where ATP8A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP8A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.547	<.001	12	view →
COAD	Male	All	−0.377	<.001	10	view →
LUAD	Female	III,IV	−1.433	<.001	9	view →
LIHC	Male	All	+0.072	<.001	7	view →
THCA	All	All	+0.278	<.001	5	view →
BRCA	All	III,IV	+1.009	.004	3	view →
LUSC	Female	All	−0.865	<.001	3	view →
KICH	Male	All	−0.383	.008	3	view →
PRAD	All	All	+1.472	<.001	2	view →
READ	Female	All	−0.712	.008	2	view →
ESCA	All	All	−0.771	.040	1	view →
KIRP	Female	All	+0.594	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ATP8A2–HNSC

Open the HNSC breakdown →