ATP6V0A4

Across TCGA patient cohorts, ATP6V0A4 mutation is significantly associated with the RNA expression of many other genes, with 2,909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V0A4-associated genes across cancer lineages are DONSON, CHAF1B, and MTFP1. Each is linked with ATP6V0A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP6V0A4-to-partner and partner-to-ATP6V0A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DONSON grouped by ATP6V0A4-low versus ATP6V0A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V0A4→partner) and Y-score (partner→ATP6V0A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DONSON →	+0.378	+2.423	.006	.001	3	4
UCEC	CHAF1B →	+0.500	+1.864	.002	.004	3	4
UCEC	MTFP1 →	+0.547	+2.818	<.001	.001	3	4
UCEC	PGAM5 →	+0.533	+1.938	<.001	.001	3	4
SKCM	ICMT →	+0.355	+1.655	.001	.001	3	3
SKCM	SDHB →	+0.410	+1.839	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,909 associations by consensus.

DONSON by ATP6V0A4 expression — UCEC

Explore this box plot interactively →