ATP6V0A4

Across TCGA pan-cancer cohorts, ATP6V0A4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ATP6V0A4 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ATP6V0A4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP6V0A4 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

COAD, MESO, and SCLC are the cancer types where ATP6V0A4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.570	0.757	<.001	107	view →
MESO	DFS	Tertile	All	0.262	0.519	<.001	84	view →
SCLC	OS	Tertile	II,III,IV	0.139	0.842	<.001	54	view →
KIRP	DFS	Median	IV	0.038	0.594	.002	40	view →
LIHC	OS	Tertile	All	0.579	0.758	<.001	37	view →
UVM	DFS	Median	All	0.405	0.716	.009	30	view →
ESCA	OS	Median	II,III,IV	0.800	0.617	.005	24	view →
BRCA	OS	Tertile	II,III,IV	0.892	0.942	.009	16	view →
HNSC	OS	Quartile	III,IV	0.508	0.340	.014	14	view →
PAAD	OS	Quartile	II,III,IV	0.433	0.611	.010	12	view →
PRAD	DFS	Quartile	All	0.905	0.657	.012	12	view →
KIRC	DFS	Quartile	All	0.775	0.579	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ATP6V0A4–COAD (DFS)

Open the COAD breakdown →