ATP6V0A4

Across TCGA pan-cancer cohorts, ATP6V0A4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATP6V0A4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP6V0A4 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP6V0A4 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where ATP6V0A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP6V0A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−6.683	<.001	12	view →
HNSC	Male	II,III,IV	−3.378	<.001	12	view →
KIRP	Male	II,III,IV	−6.237	<.001	11	view →
UCEC	All	All	+0.858	<.001	6	view →
THCA	All	All	+0.052	.002	6	view →
KICH	Female	All	+1.500	<.001	5	view →
BLCA	All	All	+0.820	.015	5	view →
COAD	Male	All	+0.044	<.001	4	view →
PRAD	All	All	−0.931	<.001	2	view →
PAAD	All	All	+0.399	.035	2	view →
LUAD	All	All	+0.417	.048	1	view →
READ	All	All	+0.236	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATP6V0A4–KIRC

Open the KIRC breakdown →