ATP6V0A4

Across TCGA cell cohorts, ATP6V0A4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible ATP6V0A4-associated genes across cancer lineages are SPINK8, SPATA19, and BTBD16. Each is linked with ATP6V0A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V0A4-to-partner and partner-to-ATP6V0A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK8 grouped by ATP6V0A4-low versus ATP6V0A4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V0A4→partner) and Y-score (partner→ATP6V0A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINK8 →	+0.438	+5.228	<.001	.005	3	2
SOFT_TISSUE	SPATA19 →	+0.030	+5.977	<.001	.001	3	1
BLOOD_Leukemia	BTBD16 →	+0.054	+3.281	.002	.003	3	1
BLOOD_Leukemia	PLEKHS1 →	+0.077	+2.814	<.001	.008	3	1
BLOOD_Leukemia	GAST →	+0.051	+2.824	.002	.007	3	1
LUNG_NSCLC_LUAD	DPRX →	+0.328	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

SPINK8 by ATP6V0A4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →