ATP5F1A

Across TCGA cell cohorts, ATP5F1A mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATP5F1A-associated genes across cancer lineages are MSGN1, TBC1D21, and TAFA1. Each is linked with ATP5F1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5F1A-to-partner and partner-to-ATP5F1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by ATP5F1A-low versus ATP5F1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5F1A→partner) and Y-score (partner→ATP5F1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.176	+3.155	<.001	.008	3	1
BLOOD_Leukemia	R3HDML →	+0.011	+4.247	<.001	.004	3	1
BLOOD_Leukemia	LBX1 →	+0.003	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSGN1 by ATP5F1A expression — LARGE_INTESTINE

Explore this box plot interactively →