ATP5F1A

Across TCGA pan-cancer cohorts, ATP5F1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP5F1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP5F1A RNA is repressed in tumor relative to normal tissue. In most cancer types ATP5F1A is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where ATP5F1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5F1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.255	<.001	11	view →
COAD	All	IV	−1.105	<.001	10	view →
HNSC	Male	All	−0.639	<.001	10	view →
THCA	Male	III,IV	−0.761	<.001	9	view →
KIRP	Male	III,IV	−1.184	<.001	8	view →
BLCA	All	All	−0.297	.012	8	view →
LIHC	Female	II,III,IV	+0.829	<.001	7	view →
READ	All	All	−1.003	<.001	5	view →
CHOL	All	All	+0.728	.002	5	view →
LUSC	Male	All	+0.447	<.001	4	view →
BRCA	Female	All	−0.140	.018	4	view →
PAAD	All	All	−0.664	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP5F1A–KIRC

Open the KIRC breakdown →