ATP2B2

Across TCGA patient cohorts, ATP2B2 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2B2-associated genes across cancer lineages are PKC-delta_pS664, Ku80, and eIF4E. Each is linked with ATP2B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP2B2-to-partner and partner-to-ATP2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by ATP2B2-low versus ATP2B2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2B2→partner) and Y-score (partner→ATP2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-delta_pS664 →	-0.176	-3.000	.002	.033	3	3
SKCM	Ku80 →	+0.232	+2.000	.004	.007	3	3
UCEC	eIF4E →	+0.166	+2.335	.002	<.001	3	3
COAD	MIG-6 →	+0.089	+1.498	.005	.032	3	3
COAD	mTOR_pS2448 →	-0.162	-2.567	.005	.009	3	3
COAD	PAI-1 →	+0.461	+2.115	.016	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

PKC-delta_pS664 by ATP2B2 expression — STAD

Explore this box plot interactively →