ATP2B2

Across TCGA pan-cancer cohorts, ATP2B2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ATP2B2 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ATP2B2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ATP2B2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRC, PAAD, and CHOL are the cancer types where ATP2B2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.853	0.728	<.001	61	view →
PAAD	DFS	Quartile	All	0.555	0.206	<.001	52	view →
CHOL	DFS	Quartile	II,III,IV	0.144	0.689	.004	35	view →
UVM	OS	Median	II,III,IV	0.872	0.575	.008	31	view →
HNSC	DFS	Median	IV	0.690	0.466	<.001	30	view →
LUAD	DFS	Tertile	IV	0.473	0.865	.002	18	view →
THYM	DFS	Quartile	II,III,IV	0.780	0.970	.008	15	view →
BLCA	OS	Quartile	All	0.705	0.411	.005	14	view →
UCEC	OS	Quartile	All	0.575	0.804	.012	14	view →
KIRP	DFS	Tertile	All	0.922	0.811	.023	9	view →
READ	DFS	Quartile	IV	0.326	0.918	.040	8	view →
SKCM	OS	Median	IV	0.710	0.180	.006	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ATP2B2–KIRC (OS)

Open the KIRC breakdown →