ATP2B2

Across TCGA pan-cancer cohorts, ATP2B2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ATP2B2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP2B2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP2B2 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where ATP2B2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP2B2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.828	<.001	12	view →
COAD	Male	II,III,IV	−0.134	<.001	10	view →
KICH	Female	III,IV	+3.790	<.001	8	view →
HNSC	Male	All	−1.027	<.001	8	view →
KIRP	All	All	+0.716	.002	6	view →
READ	All	All	−0.172	<.001	5	view →
BRCA	All	III,IV	−0.442	.006	4	view →
THCA	Female	All	−0.043	<.001	4	view →
LIHC	Female	All	+0.873	.021	3	view →
CHOL	All	All	−1.845	.015	2	view →
UCEC	All	IV	−1.514	.019	2	view →
STAD	Male	All	−0.321	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ATP2B2–KIRC

Open the KIRC breakdown →