ATP11B

Across TCGA patient cohorts, ATP11B mutation is significantly associated with the RNA expression of many other genes, with 2,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP11B-associated genes across cancer lineages are RNA5SP420, RNA5SP412, and TRAJ12. Each is linked with ATP11B in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP11B-to-partner and partner-to-ATP11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP420 grouped by ATP11B-low versus ATP11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP11B→partner) and Y-score (partner→ATP11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP420 →	+0.395	+1.431	<.001	.007	3	3
UCEC	RNA5SP412 →	+0.419	+1.431	<.001	.007	3	3
UCS	TRAJ12 →	+0.711	+5.087	<.001	.006	3	2
LIHC	SPATA48 →	+0.015	+4.647	<.001	.007	3	2
CESC	SFPQP1 →	+0.024	+5.342	<.001	.002	3	2
CESC	MIR3135A →	+0.420	+4.503	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,576 associations by consensus.

RNA5SP420 by ATP11B expression — UCEC

Explore this box plot interactively →