ATP11B

Across TCGA pan-cancer cohorts, ATP11B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ATP11B data layer compared with 7 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ATP11B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP11B expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

UCEC, KIRC, and ACC are the cancer types where ATP11B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.544	0.740	<.001	96	view →
KIRC	OS	Quartile	All	0.740	0.546	<.001	78	view →
ACC	DFS	Tertile	All	0.481	0.876	<.001	54	view →
LGG	OS	Median	All	0.752	0.875	<.001	47	view →
PAAD	OS	Quartile	All	0.218	0.536	.005	43	view →
LUSC	OS	Quartile	All	0.831	0.689	.007	35	view →
SKCM	OS	Quartile	All	0.392	0.290	.001	26	view →
LUAD	OS	Tertile	All	0.774	0.859	.009	23	view →
COAD	DFS	Median	All	0.703	0.417	.001	16	view →
CHOL	DFS	Median	All	0.682	0.189	.008	15	view →
OV	DFS	Tertile	II,III,IV	0.502	0.595	.015	12	view →
KICH	DFS	Quartile	III,IV	0.171	1.000	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ATP11B–UCEC (DFS)

Open the UCEC breakdown →