ATP10D

Across TCGA patient cohorts, ATP10D mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP10D-associated genes across cancer lineages are INPP4B, 4E-BP1, and MAPK_pT202_Y204. Each is linked with ATP10D in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP10D-to-partner and partner-to-ATP10D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ATP10D-low versus ATP10D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP10D→partner) and Y-score (partner→ATP10D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.184	-1.362	.047	.031	3	3
UCEC	4E-BP1 →	+0.324	+1.736	<.001	<.001	3	3
LUSC	MAPK_pT202_Y204 →	+0.384	+3.169	.006	.017	3	2
UCEC	Caspase-8 →	-0.251	-2.973	<.001	<.001	3	2
UCEC	eIF4E →	+0.168	+2.247	.005	.001	3	2
UCEC	Notch1 →	+0.151	+1.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

INPP4B by ATP10D expression — UCEC

Explore this box plot interactively →