ATOX1

Across TCGA patient cohorts, ATOX1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATOX1-associated genes across cancer lineages are OR8S21P, RNU6-642P, and RNU4-58P. Each is linked with ATOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATOX1-to-partner and partner-to-ATOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8S21P grouped by ATOX1-low versus ATOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATOX1→partner) and Y-score (partner→ATOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR8S21P →	+0.558	+5.484	<.001	.005	3	1
UCEC	RNU6-642P →	+0.846	+5.242	<.001	.007	3	1
UCEC	RNU4-58P →	+0.674	+5.133	<.001	.008	3	1
UCEC	IGHD6-19 →	+1.597	+5.420	<.001	.005	3	1
UCEC	ATG4AP1 →	+0.160	+5.031	.003	.009	3	1
UCEC	NPAP1P4 →	+0.051	+5.081	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR8S21P by ATOX1 expression — UCEC

Explore this box plot interactively →