ATG2A

Across TCGA patient cohorts, ATG2A mutation is significantly associated with the RNA expression of many other genes, with 6,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG2A-associated genes across cancer lineages are SLC25A27, APCDD1, and RPL36AL. Each is linked with ATG2A in more than 4 cancer types. Because this analysis shows association rather than direction, both ATG2A-to-partner and partner-to-ATG2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A27 grouped by ATG2A-low versus ATG2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG2A→partner) and Y-score (partner→ATG2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC25A27 →	-0.890	-3.074	<.001	<.001	3	4
COAD	APCDD1 →	-1.591	-3.087	<.001	<.001	3	4
COAD	RPL36AL →	+0.537	+3.848	<.001	<.001	3	4
UCEC	UQCRH →	+0.642	+1.562	.002	<.001	3	4
COAD	ACTG1 →	+0.320	+4.169	.009	<.001	3	4
COAD	TIPIN →	+0.517	+3.087	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,836 associations by consensus.

SLC25A27 by ATG2A expression — COAD

Explore this box plot interactively →