ATG2A

Across TCGA pan-cancer cohorts, ATG2A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ATG2A data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATG2A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ATG2A expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, HNSC, and KICH are the cancer types where ATG2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.754	0.351	.003	58	view →
HNSC	DFS	Tertile	All	0.511	0.296	.001	37	view →
KICH	DFS	Median	All	0.812	0.970	.027	36	view →
UCS	DFS	Median	IV	0.885	0.440	.015	30	view →
ACC	DFS	Tertile	All	0.230	0.696	<.001	30	view →
KIRC	DFS	Median	All	0.751	0.506	<.001	20	view →
LIHC	DFS	Median	II,III,IV	0.242	0.427	.010	18	view →
SARC	DFS	Tertile	All	0.714	0.501	<.001	16	view →
COAD	DFS	Tertile	IV	0.308	0.865	.003	13	view →
LUSC	DFS	Median	III,IV	0.434	0.884	.009	12	view →
CHOL	OS	Tertile	II,III,IV	0.751	0.283	.028	9	view →
SCLC	OS	Tertile	All	0.549	0.253	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ATG2A–UVM (DFS)

Open the UVM breakdown →