ATG2A

Across TCGA patient cohorts, ATG2A mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG2A-associated genes across cancer lineages are Cyclin-B1, PCNA, and Rad50. Each is linked with ATG2A in more than 4 cancer types. Because this analysis shows association rather than direction, both ATG2A-to-partner and partner-to-ATG2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ATG2A-low versus ATG2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG2A→partner) and Y-score (partner→ATG2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.569	+1.999	<.001	<.001	3	5
STAD	PCNA →	+0.266	+3.169	.049	.018	2	5
COAD	Rad50 →	-0.432	-2.674	<.001	.005	3	4
LUSC	4E-BP1 →	+0.587	+2.816	.005	.036	2	4
LUSC	Cyclin-E2 →	+0.215	+2.816	.002	.036	3	3
STAD	ER-alpha_pS118 →	+0.097	+3.201	.015	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Cyclin-B1 by ATG2A expression — UCEC

Explore this box plot interactively →