ATG2A

Across TCGA cell cohorts, ATG2A mutation is significantly associated with the RNA expression of many other genes, with 1,686 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATG2A-associated genes across cancer lineages are C1orf146, TTI2, and SIX5. Each is linked with ATG2A in more than 2 cancer types. Because this analysis shows association rather than direction, both ATG2A-to-partner and partner-to-ATG2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by ATG2A-low versus ATG2A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG2A→partner) and Y-score (partner→ATG2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C1orf146 →	+0.023	+4.643	<.001	.008	3	3
LARGE_INTESTINE	TTI2 →	+0.519	+2.043	.002	.001	3	3
LARGE_INTESTINE	SIX5 →	+0.763	+2.545	<.001	<.001	3	3
SOFT_TISSUE	LRRC3C →	+0.022	+2.727	.002	.001	3	2
LUNG_NSCLC_LUAD	TRIML1 →	+0.124	+4.786	<.001	<.001	3	2
LARGE_INTESTINE	DMC1 →	+0.862	+2.459	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,686 associations by consensus.

C1orf146 by ATG2A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →