ATG14

Across TCGA cell cohorts, ATG14 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATG14-associated genes across cancer lineages are MAGEB4, OR10W1, and TPSG1. Each is linked with ATG14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG14-to-partner and partner-to-ATG14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ATG14-low versus ATG14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG14→partner) and Y-score (partner→ATG14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	TPSG1 →	+0.563	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	ACTRT1 →	+0.010	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR11H1 →	+0.034	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	IRS4 →	+0.504	+5.794	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MAGEB4 by ATG14 expression — LARGE_INTESTINE

Explore this box plot interactively →