ATG14

Across TCGA pan-cancer cohorts, ATG14 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ATG14’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ATG14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATG14 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

LIHC, HNSC, and THCA are the cancer types where ATG14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.026	<.001	8	view →
HNSC	Female	III,IV	+0.996	<.001	8	view →
THCA	All	All	−0.332	<.001	7	view →
CHOL	All	All	+1.686	<.001	5	view →
LUSC	Male	All	+0.359	<.001	5	view →
BRCA	Female	All	−0.294	<.001	4	view →
KIRP	All	II,III,IV	+0.564	.008	3	view →
LUAD	All	All	+0.245	.002	3	view →
UCEC	All	All	−0.471	.003	2	view →
PRAD	All	All	−0.188	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ATG14–LIHC

Open the LIHC breakdown →