ATF5

Across TCGA patient cohorts, ATF5 mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF5-associated genes across cancer lineages are LINC02104, H3C8, and TRBV12-4. Each is linked with ATF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF5-to-partner and partner-to-ATF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02104 grouped by ATF5-low versus ATF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF5→partner) and Y-score (partner→ATF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02104 →	+0.229	+3.830	.008	.001	3	1
UCEC	H3C8 →	+1.077	+3.534	<.001	.002	3	1
UCEC	TRBV12-4 →	+0.777	+3.513	<.001	.005	3	1
UCEC	RNA5SP412 →	+0.518	+2.481	.007	.006	3	1
SKCM	MRGPRX8P →	+0.035	+4.265	<.001	.001	3	1
SKCM	RN7SL575P →	+0.080	+3.302	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

LINC02104 by ATF5 expression — UCEC

Explore this box plot interactively →