ATF5

Across TCGA pan-cancer cohorts, ATF5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ATF5 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ATF5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATF5 expression acts as an unfavorable survival marker, although some lineages such as CESC and SCLC show a favorable association.

ACC, CESC, and KIRC are the cancer types where ATF5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.369	0.790	<.001	98	view →
CESC	OS	Tertile	All	0.944	0.828	.001	78	view →
KIRC	DFS	Median	All	0.754	0.852	<.001	69	view →
LGG	OS	Median	All	0.710	0.906	<.001	54	view →
BLCA	DFS	Median	IV	0.214	0.486	<.001	45	view →
THCA	DFS	Tertile	All	0.829	0.979	.004	36	view →
LUSC	DFS	Quartile	III,IV	0.134	0.951	<.001	36	view →
KIRP	OS	Median	All	0.772	0.979	.001	21	view →
MESO	OS	Quartile	All	0.305	0.559	.006	18	view →
COAD	DFS	Quartile	IV	0.300	0.675	.002	14	view →
KICH	DFS	Quartile	All	0.626	1.000	.006	13	view →
SCLC	DFS	Quartile	III,IV	0.590	0.210	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ATF5–ACC (DFS)

Open the ACC breakdown →