ATF4P4

Across TCGA patient cohorts, ATF4P4 mutation is significantly associated with the RNA expression of many other genes, with 2,885 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF4P4-associated genes across cancer lineages are DCPS, DTL, and CDCA2. Each is linked with ATF4P4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATF4P4-to-partner and partner-to-ATF4P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCPS grouped by ATF4P4-low versus ATF4P4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4P4→partner) and Y-score (partner→ATF4P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCPS →	+0.378	+1.925	.003	.004	3	3
UCEC	DTL →	+0.550	+2.431	.002	.001	3	3
UCEC	CDCA2 →	+0.687	+2.169	<.001	<.001	3	3
UCEC	CENPU →	+0.513	+1.925	.004	.004	3	3
UCEC	DONSON →	+0.451	+2.534	<.001	<.001	3	3
UCEC	SFXN1 →	+0.480	+2.485	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,885 associations by consensus.

DCPS by ATF4P4 expression — UCEC

Explore this box plot interactively →