ATF4P4

Across TCGA pan-cancer cohorts, ATF4P4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ATF4P4 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ATF4P4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATF4P4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

ACC, HNSC, and CESC are the cancer types where ATF4P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.267	0.620	<.001	101	view →
HNSC	OS	Tertile	II,III,IV	0.476	0.253	<.001	92	view →
CESC	DFS	Tertile	All	0.644	0.422	.001	62	view →
LIHC	OS	Median	All	0.440	0.643	<.001	57	view →
KICH	OS	Tertile	III,IV	0.194	0.885	.004	39	view →
SKCM	OS	Quartile	III,IV	0.862	0.606	<.001	37	view →
THCA	DFS	Tertile	III,IV	0.450	0.936	.005	27	view →
MESO	OS	Tertile	II,III,IV	0.253	0.498	.004	20	view →
UVM	OS	Median	III,IV	0.589	0.966	.011	20	view →
THYM	DFS	Median	II,III,IV	0.893	0.548	.001	17	view →
READ	DFS	Quartile	All	0.940	0.738	.010	16	view →
LUAD	OS	Tertile	II,III,IV	0.654	0.838	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ATF4P4–ACC (DFS)

Open the ACC breakdown →