ATF4P4

Across TCGA pan-cancer cohorts, ATF4P4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ATF4P4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATF4P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATF4P4 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where ATF4P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATF4P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.189	<.001	12	view →
BRCA	All	All	−0.079	<.001	6	view →
COAD	Female	II,III,IV	+0.446	<.001	5	view →
CHOL	All	All	+0.219	<.001	5	view →
BLCA	Male	III,IV	−0.264	.039	3	view →
KIRP	All	III,IV	+0.098	.019	3	view →
LIHC	All	II,III,IV	+0.078	.013	3	view →
PAAD	All	All	−0.189	.031	2	view →
LUSC	Female	III,IV	+0.175	.022	2	view →
READ	Male	All	+0.173	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ATF4P4–KIRC

Open the KIRC breakdown →