ATF4P4

Across TCGA patient cohorts, ATF4P4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF4P4-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and Notch1. Each is linked with ATF4P4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATF4P4-to-partner and partner-to-ATF4P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ATF4P4-low versus ATF4P4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4P4→partner) and Y-score (partner→ATF4P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.264	+2.832	.016	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.052	+2.815	.015	.036	3	2
UCEC	Notch1 →	+0.161	+1.495	.001	.034	3	2
UCEC	PDCD4 →	-0.536	-2.459	.001	.018	3	2
UCEC	Annexin-1 →	+0.685	+2.807	<.001	.002	3	2
UCEC	Bax →	+0.222	+1.594	.011	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by ATF4P4 expression — COAD

Explore this box plot interactively →