ASTE1

Across TCGA patient cohorts, ASTE1 mutation is significantly associated with the RNA expression of many other genes, with 4,663 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTE1-associated genes across cancer lineages are PSMD7P1, MIR3661, and RNU6-42P. Each is linked with ASTE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASTE1-to-partner and partner-to-ASTE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD7P1 grouped by ASTE1-low versus ASTE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTE1→partner) and Y-score (partner→ASTE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD7P1 →	+0.199	+1.598	<.001	.003	3	2
UCEC	MIR3661 →	+0.591	+1.778	<.001	<.001	3	2
UCEC	RNU6-42P →	+0.478	+1.741	.001	.002	3	2
UCEC	RNA5SP198 →	+0.234	+2.243	.003	.004	3	2
UCEC	RPA2P2 →	+0.187	+1.485	<.001	.007	3	2
LUSC	MIR4797 →	+0.641	+4.188	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,663 associations by consensus.

PSMD7P1 by ASTE1 expression — UCEC

Explore this box plot interactively →