ASTE1

Across TCGA pan-cancer cohorts, ASTE1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ASTE1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ASTE1 RNA is repressed in tumor relative to normal tissue. In most cancer types ASTE1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where ASTE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASTE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.028	<.001	11	view →
HNSC	Male	IV	+1.034	<.001	10	view →
KIRC	Female	All	+0.483	<.001	8	view →
LIHC	Male	All	+0.461	<.001	7	view →
KICH	Female	All	−1.146	<.001	5	view →
CHOL	All	All	+1.007	<.001	5	view →
BLCA	All	All	+0.512	.008	5	view →
STAD	All	II,III,IV	+0.394	.010	4	view →
LUSC	All	All	+0.464	<.001	3	view →
UCEC	All	All	−0.562	<.001	2	view →
COAD	Female	All	−0.325	.024	2	view →
ESCA	Female	All	+0.706	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ASTE1–THCA

Open the THCA breakdown →