ASPRV1

Across TCGA patient cohorts, ASPRV1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPRV1-associated genes across cancer lineages are GAPDH, MEK1, and PDCD4. Each is linked with ASPRV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPRV1-to-partner and partner-to-ASPRV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ASPRV1-low versus ASPRV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPRV1→partner) and Y-score (partner→ASPRV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.584	+2.321	.010	.033	3	2
UCEC	MEK1 →	+0.465	+2.906	.002	.001	3	2
UCEC	PDCD4 →	-0.633	-2.321	.001	.033	3	2
UCEC	Rab25 →	-0.340	-1.700	.015	.044	3	2
UCEC	VEGFR2 →	+0.350	+2.235	.005	.006	3	2
UCEC	ATM →	-0.674	-3.308	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

GAPDH by ASPRV1 expression — UCEC

Explore this box plot interactively →