ASPRV1

Across TCGA pan-cancer cohorts, ASPRV1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ASPRV1 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ASPRV1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ASPRV1 expression acts as an unfavorable survival marker, although some lineages such as CESC and KIRP show a favorable association.

CESC, KIRP, and UCS are the cancer types where ASPRV1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.877	0.722	.001	78	view →
KIRP	DFS	Tertile	II,III,IV	0.822	0.255	.001	54	view →
UCS	OS	Median	All	0.803	0.539	.003	44	view →
DLBC	DFS	Tertile	II,III,IV	0.259	1.000	.004	38	view →
ACC	DFS	Tertile	All	0.288	0.688	.001	36	view →
MESO	OS	Tertile	IV	0.951	0.213	.002	33	view →
KIRC	OS	Quartile	All	0.903	0.778	.001	29	view →
SARC	DFS	Median	All	0.701	0.520	<.001	26	view →
UCEC	DFS	Median	IV	0.725	0.216	.001	24	view →
LIHC	OS	Quartile	II,III,IV	0.663	0.329	.002	24	view →
LGG	DFS	Tertile	All	0.770	0.882	<.001	22	view →
READ	DFS	Tertile	IV	0.322	0.723	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ASPRV1–CESC (DFS)

Open the CESC breakdown →