ASPN

Across TCGA patient cohorts, ASPN mutation is significantly associated with the RNA expression of many other genes, with 814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPN-associated genes across cancer lineages are SNRPGP7, RNU2-47P, and DYNLT3P2. Each is linked with ASPN in more than 2 cancer types. Because this analysis shows association rather than direction, both ASPN-to-partner and partner-to-ASPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by ASPN-low versus ASPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPN→partner) and Y-score (partner→ASPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP7 →	+0.171	+2.920	<.001	.008	3	3
UCEC	RNU2-47P →	+0.077	+3.973	<.001	.006	3	2
UCEC	DYNLT3P2 →	+0.338	+2.240	<.001	.003	3	2
UCEC	MTCYBP10 →	+0.027	+4.055	.005	<.001	3	2
LUAD	RNA5SP35 →	+0.604	+4.798	<.001	.006	3	2
BRCA	SPATA31A5 →	+0.009	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 814 associations by consensus.

SNRPGP7 by ASPN expression — UCEC

Explore this box plot interactively →