ASPN

Across TCGA pan-cancer cohorts, ASPN RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ASPN data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ASPN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ASPN expression acts as an unfavorable survival marker, although some lineages such as UCS and DLBC show a favorable association.

KIRP, SCLC, and UCS are the cancer types where ASPN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.564	0.800	<.001	163	view →
SCLC	OS	Median	II,III,IV	0.559	0.808	<.001	55	view →
UCS	DFS	Tertile	III,IV	0.573	0.083	<.001	54	view →
UVM	DFS	Quartile	III,IV	0.185	0.901	.001	31	view →
LGG	OS	Tertile	All	0.840	0.938	<.001	30	view →
KICH	DFS	Median	II,III,IV	0.589	1.000	.006	18	view →
STAD	OS	Quartile	All	0.360	0.599	.026	17	view →
BLCA	OS	Tertile	All	0.355	0.597	.014	14	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	12	view →
DLBC	DFS	Quartile	All	0.838	0.481	.020	9	view →
HNSC	DFS	Quartile	IV	0.383	0.274	.019	7	view →
COAD	OS	Quartile	IV	0.848	0.237	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ASPN–KIRP (OS)

Open the KIRP breakdown →