ASPN

Across TCGA pan-cancer cohorts, ASPN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ASPN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ASPN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ASPN is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KICH, and KIRP are the cancer types where ASPN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASPN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+3.247	<.001	12	view →
KICH	Female	II,III,IV	−2.258	<.001	8	view →
KIRP	Male	All	−1.571	<.001	8	view →
UCEC	All	All	−3.644	<.001	6	view →
BRCA	All	III,IV	+2.263	<.001	6	view →
LUAD	Male	II,III,IV	+2.243	<.001	5	view →
STAD	Male	II,III,IV	+1.702	.004	4	view →
LIHC	Male	All	−0.909	.001	4	view →
KIRC	Male	II,III,IV	−0.694	.002	4	view →
BLCA	Female	All	+2.038	.014	3	view →
PRAD	All	All	+1.214	<.001	2	view →
THCA	Female	II,III,IV	−1.029	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ASPN–HNSC

Open the HNSC breakdown →