ASPA

Across TCGA patient cohorts, ASPA mutation is significantly associated with the RNA expression of many other genes, with 1,641 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPA-associated genes across cancer lineages are SEPTIN14P1, MIR6806, and RNY4P27. Each is linked with ASPA in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPA-to-partner and partner-to-ASPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P1 grouped by ASPA-low versus ASPA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPA→partner) and Y-score (partner→ASPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEPTIN14P1 →	+0.127	+4.612	<.001	.006	3	2
CESC	MIR6806 →	+0.688	+4.409	.002	.006	3	2
UCEC	RNY4P27 →	+0.108	+2.868	.009	.009	3	2
SKCM	RN7SL524P →	+0.132	+3.801	<.001	.007	3	2
SKCM	RNU6ATAC26P →	+0.440	+4.254	<.001	.003	3	2
SKCM	MTCYBP45 →	+0.068	+4.254	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,641 associations by consensus.

SEPTIN14P1 by ASPA expression — LUAD

Explore this box plot interactively →