ASPA

Across TCGA pan-cancer cohorts, ASPA RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of ASPA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ASPA RNA is repressed in tumor relative to normal tissue. In most cancer types ASPA is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where ASPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.702	<.001	12	view →
KICH	Male	III,IV	−3.937	<.001	11	view →
BLCA	Male	All	−2.630	<.001	11	view →
LUAD	Female	III,IV	−1.961	<.001	11	view →
HNSC	Male	IV	−1.251	<.001	11	view →
THCA	All	IV	−1.170	<.001	11	view →
LUSC	Female	II,III,IV	−2.368	<.001	9	view →
KIRP	All	III,IV	−2.076	<.001	9	view →
BRCA	All	III,IV	−2.256	<.001	8	view →
STAD	All	All	−1.314	<.001	8	view →
LIHC	Male	III,IV	−1.165	<.001	7	view →
UCEC	All	All	−2.514	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

ASPA–COAD

Open the COAD breakdown →