ASIC4

Across TCGA patient cohorts, ASIC4 mutation is significantly associated with the RNA expression of many other genes, with 2,945 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASIC4-associated genes across cancer lineages are SLC35B1, PIMREG, and RHOA. Each is linked with ASIC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASIC4-to-partner and partner-to-ASIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35B1 grouped by ASIC4-low versus ASIC4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC4→partner) and Y-score (partner→ASIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC35B1 →	+0.472	+3.351	<.001	.005	3	3
COAD	PIMREG →	+0.796	+3.459	<.001	.005	3	3
COAD	RHOA →	+0.459	+3.342	<.001	.005	3	3
PRAD	OR6M1 →	+0.071	+5.053	<.001	.009	3	3
READ	RNU11-4P →	+0.302	+3.594	<.001	.006	3	3
READ	LINC02530 →	+0.146	+3.594	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,945 associations by consensus.

SLC35B1 by ASIC4 expression — COAD

Explore this box plot interactively →