ASIC4

Across TCGA pan-cancer cohorts, ASIC4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ASIC4 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ASIC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ASIC4 expression acts as an unfavorable survival marker, although some lineages such as LGG and LUAD show a favorable association.

MESO, KIRC, and KIRP are the cancer types where ASIC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.271	0.511	<.001	109	view →
KIRC	DFS	Tertile	II,III,IV	0.385	0.655	<.001	79	view →
KIRP	OS	Tertile	II,III,IV	0.297	1.000	<.001	73	view →
LIHC	DFS	Quartile	All	0.401	0.602	<.001	66	view →
LGG	OS	Median	All	0.523	0.368	<.001	54	view →
UVM	DFS	Median	All	0.394	1.000	<.001	37	view →
ACC	OS	Median	All	0.381	0.849	.001	24	view →
PRAD	DFS	Median	All	0.822	0.940	<.001	22	view →
READ	DFS	Median	IV	0.349	0.805	.001	19	view →
CHOL	OS	Median	All	0.367	0.737	.006	17	view →
COAD	DFS	Quartile	All	0.438	0.634	.005	10	view →
DLBC	OS	Median	IV	0.527	1.000	.033	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ASIC4–MESO (DFS)

Open the MESO breakdown →