ASIC2

Across TCGA cell cohorts, ASIC2 mutation is significantly associated with the RNA expression of many other genes, with 908 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASIC2-associated genes across cancer lineages are SPATA31E1, AVPR1B, and KRTAP2-1. Each is linked with ASIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASIC2-to-partner and partner-to-ASIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31E1 grouped by ASIC2-low versus ASIC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASIC2→partner) and Y-score (partner→ASIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPATA31E1 →	+0.038	+4.095	<.001	.009	3	1
SKIN	AVPR1B →	+0.009	+4.415	<.001	.007	3	1
SKIN	KRTAP2-1 →	+0.193	+4.415	<.001	.007	3	1
OVARY	ODF4 →	+0.035	+5.196	<.001	.005	3	1
LARGE_INTESTINE	PICK1 →	+0.768	+3.212	.001	.006	3	1
LARGE_INTESTINE	TTLL1 →	+0.738	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 908 associations by consensus.

SPATA31E1 by ASIC2 expression — SKIN

Explore this box plot interactively →