ASIC2

Across TCGA pan-cancer cohorts, ASIC2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ASIC2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ASIC2 RNA is repressed in tumor relative to normal tissue. In most cancer types ASIC2 is over-expressed in tumor, although a few such as KIRC and READ show the opposite, repressed pattern.

KIRC, READ, and PAAD are the cancer types where ASIC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASIC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−0.922	<.001	12	view →
READ	All	III,IV	−0.365	.022	2	view →
PAAD	All	All	+0.172	.043	2	view →
THCA	All	All	+0.046	.045	2	view →
BRCA	All	All	+0.173	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ASIC2–KIRC

Open the KIRC breakdown →